http://repoz.kgmu.kz/handle/123456789/46 2026-04-22T13:49:06Z http://repoz.kgmu.kz/handle/123456789/662 Interaction of zinc of pancreatic ß-cells with cystein as possible cause of its protective activity MeyramovI, G. G.; Laryushina, Ye. M.; Alina, A. R.; Abdraimova-Meyramova, A. G. It is known that zinc, contained in β-cells of the pancreas, takes an important part in the formation of its deposited storage form in the cell, due to which not all of the cell-synthesized hormone, but only a certain amount of it, enters the blood, regulating carbohydrate metabolism and providing maintenance of blood glucose level at a constant level. It is also known that there are zinc-binding diabetogenic substances that, when ingested, bind to zinc of β-cells, forming toxic complexes, leading to destruction and cell death within 15-30 minutes. A total of 18 such substances are known, and 17 of them refer to derivatives of 8- hydroxyquinoline, some of whose representatives are components of 12 drugs (in 1970 there were 2 of them). It is also known that the preliminary introduction of the amino acid cysteine completely prevents the development of diabetes caused by zinc-binding diabetogenic substances. Presumably, this is justified by its ability to block zinc in the doses used for 24-36 h, preventing it from interacting with zinc-binding diabetogenic substances. Authors using sensitive and strictly specific methods have established that indeed, cysteine blocks islet zinc, preventing its interaction with zinc-binding diabetogenic substances. The authors believe that the blocked zinc atoms are fixed between the sulfur atom that is part of the SH group in the cysteine molecule and the oxygen atom of the carboxyl group, or between the sulfur atom and the nitrogen atom of the amino group of the cysteine molecule, as is also the case with the interaction of zinc with zinc-binding diabetogenic substances, where chelates with zinc are formed only as a result of fixing them between these atoms 2018-01-01T00:00:00Z http://repoz.kgmu.kz/handle/123456789/633 Морфометрический анализ окружающей ткани почки с применением децеллюляризированной ксенобрюшины и брюшино-фасционального лоскута при моделировании нефропексии у крыс Тусупбекова, М. М.; Абатов., Н. Т.; Абугалиев, К. Р.; Альбертон, И. Н.; Абатова, А. Н.; Асамиданов, Е. М. В статье представлен анализ окружающей ткани почки с применением децеллюляризированной ксенобрюшины и брюшино-фасционального лоскута при моделировании нефропексии путем проведения морфометрического анализа на лабораторных животных. Приведенные в статье результаты наглядно демонстрируют, что наиболее рациональным методом хирургического лечения больных является нефропексия с использованием децеллюляризированной ксенобрюшины. 2018-04-01T00:00:00Z http://repoz.kgmu.kz/handle/123456789/574 Summary of data on transcellular transport proteins involved in medical practice Chesca, A.; Pestrea, S.A.; Akhayeva, A.S.; Marchenko, A.B. The authors of the presented article address the problem of transcellular transport proteins used in medical practice. Passive transport-facilitated diffusion is mediated by permeating membrane proteins with specific characteristics. In the process of transmembrane transport, permeating molecules bind to an active site of the transporter on one side of the membrane. In this way a permeant-transporter complex is formed that crosses the bilayer, dissociating themselves on the other side of the membrane, with the purpose to release the molecule transported. Facilitated diffusion occurs depending on concentration transported molecule according to kinetics similar to the Michaelis-Menten relationship for enzymatic reactions with a single substrate. This implies that the rate of transport reaches a maximum value when it becomes independent of substrate concentration. 2021-04-01T00:00:00Z http://repoz.kgmu.kz/handle/123456789/410 Вирулентный Acinetobacter baumanni Лавриненко, А.В. В последние годы Acinetobacter baumannii является одним из важнейших нозокомиальных патогенов, распространенных по всему миру. A. baumannii известен своей способностью выживать в течение длительного периода времени в госпиталях, склонен к развитию множественной устойчивости к антибиотикам, также несомненна его роль в развитии серьезных инфекций у критических пациентов. В статье описаны основные факторы вирулентности A. baumannii – пили, липополисахариды, везикулы наружной мембраны, липазы, биопленки, эндотоксин, капсульный полисахарид, система секреции. Описанные факторы вирулентности и накопленные механизмы устойчивости формируют серьезный внутрибольничный патоген. 2020-01-22T00:00:00Z